Dean G Assimos Selected Research

glycollate oxidase

1/2019	Re: CRISPR/Cas9-Mediated Glycolate Oxidase Disruption is an Efficacious and Safe Treatment for Primary Hyperoxaluria Type I.
1/2017	Re: An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.
1/2016	Re: Glycolate Oxidase is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I.

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Dean G Assimos Research Topics

Disease

44	Kidney Calculi (Kidney Stone) 01/2021 - 10/2004
13	Nephrolithiasis 11/2020 - 01/2007
13	Urinary Calculi (Urinary Calculus) 01/2020 - 04/2002
12	Shock 01/2019 - 01/2002
10	Primary Hyperoxaluria (Oxaluria, Primary) 01/2020 - 11/2004
10	Urolithiasis 01/2020 - 05/2006
8	Calculi (Calculus) 04/2015 - 01/2003
7	Hyperoxaluria (Oxaluria) 01/2018 - 01/2006
7	Prostatic Neoplasms (Prostate Cancer) 07/2017 - 01/2014
6	Cystinuria 01/2020 - 07/2002
5	Hypercalciuria 01/2020 - 08/2013
4	Infections 01/2020 - 10/2004
4	Ureteral Calculi 01/2017 - 01/2003
3	Primary hyperoxaluria type 1 01/2021 - 05/2013
3	Calcium Oxalate Nephrolithiasis 11/2019 - 01/2016
2	Pain (Aches) 10/2020 - 01/2007
2	Hypercalcemia (Milk Alkali Syndrome) 09/2020 - 01/2017
2	Chronic Renal Insufficiency 10/2019 - 12/2017
2	Metabolic Bone Diseases (Osteopenia) 01/2018 - 08/2013
2	Primary Hyperparathyroidism 01/2018 - 01/2017
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2017 - 01/2016
2	Staghorn Calculi 04/2016 - 01/2009
2	Lithiasis 01/2016 - 08/2013
1	Autosomal Dominant Polycystic Kidney (ADPKD) 11/2020
1	Nephrosis 10/2020
1	Renal Colic 01/2020
1	Acidosis 01/2020
1	Hyperparathyroidism 01/2020
1	Ovarian Neoplasms (Ovarian Cancer) 01/2020
1	Multiple Myeloma 01/2020
1	Medullary Sponge Kidney 12/2019
1	Poisoning 11/2019
1	Epilepsy (Aura) 11/2018
1	Nephrocalcinosis 11/2018
1	Infantile Hypercalcemia 01/2018
1	Fistula 01/2018
1	Obesity 01/2018

Drug/Important Bio-Agent (IBA)

25	OxalatesIBA 01/2021 - 10/2004
20	CalciumIBA 09/2020 - 03/2008
13	Calcium OxalateIBA 01/2021 - 07/2002
5	Cystine (L-Cystine)IBA 11/2020 - 07/2002
5	Uric Acid (Urate)IBA 01/2020 - 01/2007
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2009
3	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2020 - 05/2013
3	glycollate oxidaseIBA 01/2019 - 01/2016
3	Vitamin D FDA LinkGeneric 01/2017 - 03/2014
2	Opioid Analgesics (Opioids)IBA 10/2020 - 01/2019
2	Potassium Citrate FDA LinkGeneric 12/2019 - 01/2016
2	Mucin-1 (CA 15-3 Antigen)IBA 01/2017 - 11/2016
2	ThiazidesIBA 01/2017 - 08/2013
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 10/2016 - 10/2013
2	Citric Acid (Citrate)FDA LinkGeneric 01/2009 - 03/2008
1	Tolvaptan FDA Link 11/2020
1	Ammonium CompoundsIBA 11/2020
1	symmetric dimethylarginineIBA 10/2020
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020
1	Cycloserine (Seromycin)FDA Link 01/2020
1	sodium-hydrogen exchanger regulatory factorIBA 01/2020
1	glycolic acid (glycolate)IBA 01/2020
1	Tiopronin (Thiola)FDA Link 01/2020
1	Protons (Proton)IBA 01/2020
1	Claudin-2IBA 01/2020
1	Oxidoreductases (Dehydrogenase)IBA 01/2020
1	LithiumIBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Ion Channels (Ion Channel)IBA 01/2020
1	Matrix Gla ProteinIBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 12/2019
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 11/2019
1	Ethylene Glycol (Monoethylene Glycol)IBA 11/2019
1	stiripentolIBA 11/2019
1	AcidsIBA 01/2019
1	AnionsIBA 01/2019
1	hydroxycitric acidIBA 01/2019
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2019
1	Midazolam (Versed)FDA LinkGeneric 01/2019
1	Ketamine FDA LinkGeneric 01/2019
1	Topiramate (Topamax)FDA LinkGeneric 11/2018
1	Vitamin D3 24-HydroxylaseIBA 01/2018
1	tartaric acid (tartrate)FDA Link 01/2018
1	Diphosphonates (Bisphosphonates)IBA 01/2018

Therapy/Procedure

17	Therapeutics 01/2020 - 01/2006
17	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 01/2019 - 01/2002
14	Percutaneous Nephrolithotomy 01/2020 - 01/2002
4	Bariatric Surgery 01/2020 - 01/2009
4	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2020 - 10/2010
3	Radiotherapy 07/2017 - 12/2014
3	Brachytherapy 03/2017 - 01/2014
3	Solid-State Lasers 01/2017 - 02/2005
3	Diet Therapy (Therapy, Diet) 02/2016 - 04/2009
2	Prostatectomy (Retropubic Prostatectomy) 07/2017 - 12/2014
2	Laser Lithotripsy 01/2016 - 01/2016
2	Aftercare (After-Treatment) 04/2013 - 05/2006
2	Length of Stay 01/2009 - 10/2004
1	Vegan Diet (Diet, Vegan) 01/2020
1	Gastrectomy 01/2020
1	Secondary Prevention 10/2019
1	Fecal Microbiota Transplantation 01/2019